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Research Articles

2024

Impact of Measurement Noise on Genetic Association Studies of Cardiac Function
Vukadinovic M, Renjith G, Yuan V, Kwan A, Cheng SC, Li D, Clarke SL*, Ouyang D*. Pac Symp Biocomput. 2024;29:134-147.

2023

Contemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults
Guarischi-Sousa R, Salfati E, Kho PF, Iyer KR, Hilliard AT, Herrington DM, Tsao PS, Clarke SL*, Assimes TL*. Circ Genom Precis Med. 2023 Jul 6:e004047.

Deep learning-enabled analysis of medical images identifies cardiac sphericity as an early marker of cardiomyopathy and related outcomes
Vukadinovic M, Kwan AC, Yuan V, Salerno M, Lee DC, Albert CM, Cheng S, Li D, Ouyang D*, Clarke SL*. Med. 2023 Apr 14;4(4):252-262.e3.

Genetic evidence for causal relationships between age at natural menopause and the risk of ageing-associated adverse health outcomes
Lankester J, Li J, Salfati ELI, Stefanick ML, Chan KHK, Liu S, Crandall CJ, Clarke SL*, Assimes TL*. Int J Epidemiol. 2023 Jun 6;52(3):806-816.

2022

Broad clinical manifestations of polygenic risk for coronary artery disease in the Women’s Health Initiative
Clarke SL*, Parham M*, Lankester J, Shadyab AH, Liu S, Kooperberg C, Manson JE, Tcheandjieu C, Assimes TL. Commun Med. 2022 Aug 25;2:108.

Large-scale genome-wide association study of coronary artery disease in genetically diverse populations
Tcheandjieu C*, Zhu X*, Hilliard AT*, Clarke SL*, Napolioni V, Ma S, Lee KM, Fang H, Chen F, Lu Y, Tsao NL, Raghavan S, Koyama S, Gorman BR, Vujkovic M, Klarin D, Levin MG, Sinnott-Armstrong N, Wojcik GL, Plomondon ME, Maddox TM, Waldo SW, Bick AG, Pyarajan S, Huang J, Song R, Ho YL, Buyske S, Kooperberg C, Haessler J, Loos RJF, Do R, Verbanck M, Chaudhary K, North KE, Avery CL, Graff M, Haiman CA, Le Marchand L, Wilkens LR, Bis JC, Leonard H, Shen B, Lange LA, Giri A, Dikilitas O, Kullo IJ, Stanaway IB, Jarvik GP, Gordon AS, Hebbring S, Namjou B, Kaufman KM, Ito K, Ishigaki K, Kamatani Y, Verma SS, Ritchie MD, Kember RL, Baras A, Lotta LA; Regeneron Genetics Center; CARDIoGRAMplusC4D Consortium; Biobank Japan; Million Veteran Program; Kathiresan S, Hauser ER, Miller DR, Lee JS, Saleheen D, Reaven PD, Cho K, Gaziano JM, Natarajan P, Huffman JE, Voight BF, Rader DJ, Chang KM, Lynch JA, Damrauer SM, Wilson PWF, Tang H, Sun YV, Tsao PS, O’Donnell CJ, Assimes TL. Nat Med. 2022 Aug;28(8):1679-1692.

Race and Ethnicity Stratification for Polygenic Risk Score Analyses May Mask Disparities in Hispanics
Clarke SL, Huang RDL, Hilliard AT, Tcheandjieu C, Lynch J, Damrauer SM, Chang KM, Tsao PS, Assimes TL. Circulation. 2022 Jul 19;146(3):265-267.

Coronary Artery Disease Risk of Familial Hypercholesterolemia Genetic Variants Independent of Clinically Observed Longitudinal Cholesterol Exposure
Clarke SL, Tcheandjieu C, Hilliard AT, Lee KM, Lynch J, Chang KM, Miller D, Knowles JW, O’Donnell C, Tsao PS, Rader DJ, Wilson PW, Sun YV, Gaziano JM, Assimes TL; VA Million Veteran Program. Circ Genom Precis Med. 2022 Apr;15(2):e003501. 

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